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Hydroxamic acid : ウィキペディア英語版
Hydroxamic acid

A hydroxamic acid is a class of organic compounds bearing the functional group RC(O)N(OH)R', with R and R' as organic residues and CO as a carbonyl group. They are amides (RC(O)NHR') wherein the NH center has an OH substitution. They are often used as metal chelators.
==Synthesis and reactions==
Hydroxamic acids are prepared usually from esters or acid chlorides or carboxylic acids. For the synthesis of benzohydroxamic acid, the overall equations is:〔C. R. Hauser and W. B. Renfrow, Jr "Benzohydroxamic Acid" Org. Synth. 1939, volume 19, p. 15ff.〕
:C6H5CO2Me + NH2OH → C6H5C(O)NHOH + MeOH
Hydroxamic acids can also be synthesized from aldehydes via the Angeli-Rimini reaction.
A well-known hydroxamic acid reaction is the Lossen rearrangement.

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